Transplantoux Health Evaluation Study

Evi Masschelein

Sabina De Geest
Kris Denhaerynck

Externe Projektpartner
Department of Abdominal Transplantation Surgery, University Hospitals Leuven, Leuven, Belgium (Evi Masschelein, Laurens Ceulemans, Diethard Monbaliu)

Ort der Datenerhebung
– Transplant programs, UZ Leuven, Belgium

2014 bis 2017

Reduced physical fitness, muscle weakness, decreased daily physical activity and quality of life are prevalent among all Tx-recipients calling for interventional approaches to enhance physical fitness in solid organ transplant recipients. Transplantoux  (= Transplantation + Mont Ventoux) was therefore launched by the University Hospitals of Leuven as a two yearly event with the goal to train solid organ transplant recipients in a 6-month intensive exercise program with the ultimate goal to cycle or hike up the Mont Ventoux (distance: 25.9 km, slope: 4.4%). Extending on a previous safety feasibility study in which we demonstrated that selected Tx-recipients can safely participate in an intense exercise program and that physical fitness was significantly improved after training.

The aim of the current study is to evaluate the effect of the ‘Transplantoux’ intervention in view of selected Patient Reported Outcomes (PRO). More specifically , our primary aim is to compare psychosocial and behavioral variables and HRQOL (PROs) between solid organ transplant recipients participating in Transplantoux with a matched control transplant recipients not participating (control group 1) as well as participating health controls (control group 2) from baseline until 6 months after the climb of the Mont Ventoux.

The THES study uses a quasi-experimental design. Samples are a convenience sample of participating solid organ transplant recipients in the Transplantoux intervention, a matched control sample of solid organ transplant recipients not participating in Transplantoux (control group 1) and a convenience sample of healthy controls participating in Transplantoux (control group 2). The intervention will consist of a 6 months individualized intensive exercise program, developed by a physical therapist, based on the results of a cardiopulmonary exercise test.  Selected PROs will be assessed using validated self-reported questionnaire (i.e. SF-36, DASS21 and variables from Belgian Health Survey). Barriers to physical activity will be also assessed in both groups at the end of the study. Data collection will be web-based at start, after 3, 6 and 12 months.  Using linear mixed models we will evaluate differences in evolution of PRO among groups from baseline until 6 months follow-up. 

Erwarteter Nutzen / Relevanz
This study provides information on effectiveness of a physical activity training program for transplant recipients in view of specific Patient Reported Outcomes. Insights especially in view of the control group barriers in view of physical activity can provide a basis for intervention development for this specific group.