Projektname
Brocher grant to determine solid organ transplant end-point model on relationships between influencing factors and outcomes of transplant selfmanagement behaviors

Projektleitung (PI)
Sabina De Geest; Fabienne Dobbels; Paolo De Simone

Forschungsteam
Kris Denhaerynck; Sandra Engberg; Anja Rossmeissl; Arno Schmidt-Trucksäss; Christiane Kugler; Cindy Russell; Elisa Gordon; Fabienne Dobbels; Gerda Drent; Hanna Burkhalter; Isabelle Binet; Lut Berben; Mary-Lou Klem; Monika Kirsch; Nathalie Duerinckx; Paolo De Simone; Stacee Lerret; Susan Sereika; Tracy Glass

Zusammenarbeit mit
School of Nursing, University of Missouri-Kansas City, USA; Nephrology / Transplantation Medicine, Cantonal Hospital, St.Gallen; Department of Gastroenterology and Hepatology, University Medical Center Groningen, The Netherlands; Medical College of Wisconsin, Liver Transplant and Liver Disease Program, Milwaukee, WI, USA; School of Nursing, University of Pittsburgh, PA, USA; Departement of Public Health and Primary Care KU Leuven, Belgium; UniversitäsSpital Zürich; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy; Swiss Tropical and Public Health Institute, University of Basel; Northwestern University, Chicago, IL, USA; Faculty of Health Witten University, Witten, Germany; Dep. Cardial, Thoracic, Transplant and Vascular Surgery, Hannover, Germany; Institute of Exercise and Health Sciences , Sports and Exercise Medicien, Medical Faculty, University Basel; School of Nursing, Health Sciences Library System, University of Pittsburgh, PA, USA

Laufzeit
2011 bis 2015

Projektbeschreibung
Understanding outcomes after transplantation requests a biopsychosocial model that not only focuses on biomedical factors but also includes psychosocial factors as increasing evidence shows that psychosocial factors are independent risk factors for clinical outcomes after transplantation and vice versa clinical outcomes can impact psychosocial factors. No model is currently available that describes the interrelations among psychosocial factors and their resulting effects on clinical outcomes in transplantation, a gap which hinders overall strengthening of the evidence base in this regard. The aim of this project is to develop an end-point model to close this gap. The project will include the following steps: (1) Identifying the relevant psychosocial factors and clinical endpoints in solid organ transplantation; (2) Summarizing the scientific evidence regarding the association between the selected psychosocial factors and clinical outcomes using structured literature reviews of the transplant literature; (3) Calculating effect sizes for the associations using meta analytic techniques; (4) Developing a final endpoint model that will include: (a) a graphical representation of the model and (b) a table with effect sizes for the associations between each selected psychosocial variable and selected clinical outcome; and (5) Proposing priorities for future transplant related research and the clinical management of transplant recipients.