Predictivity of Sociodemographic, Behavioral and Psychosocial Factors for Short-Term Clinical Tx Outcomes

Projektleitung (PI)
Sabina De Geest

Sonja Beckmann; Kris Denhaerynck; Binet I; Goldfarb –Rumyantzev AS; Sandhu Gurprataap S; Swiss Transplant Cohort Study; Uyen HD; for the Psychosocial Interest Group

Zusammenarbeit mit
Institute of Nursing Science, University of Basel, Switzerland; Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, USA; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA; Department of Liver transplantation, University Hospital Zurich, Switzerland; Department of Nephrology, University Hospital Insel, Bern, Switzerland; Cantonal Hospital, St Gallen, Switzerland

2011 bis 2015

The impact of pre-transplant social determinants of health on post-transplant outcomes has been limitedly studied. The Social Adaptability Index (SAI) assesses underprivileged status. Low scores were associated with poor clinical outcomes in the US population. We assessed if the SAI alone and/or in interaction with selected psychosocial or behavioural factors predicted post-transplant outcomes in adult renal transplant recipients (RTx) using data of the nation-wide open prospective Swiss Transplant Cohort Study (STCS).

The aims of this research project are:
1. To describe the baseline and evolution of sociodemographic, behavioral and psychosocial factors from pre-Tx until post-Tx within and across organ Tx groups.
2. To assess if the evolution of adherence to immunosuppressive regimen from pre- to post-Tx predicts short term clinical outcomes (i.e. acute rejection (all), FEV1 (lung Tx), GFR and CAN (renal Tx), and total bilirubin (liver Tx)) within organ Tx groups.
3. To describe the prevalence of 1) poor sleep quality and 2) daytime sleepiness from preto post-Tx and to explore if sleep quality or daytime sleepiness is associated with medication adherence.